June Trainee Seminar and Sponsored Happy Hour

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Please join us to hear from trainees conducting brain cancer and technology-related research. This is part of a special summer seminar series that will be followed by a BIBC sponsored social hour at Rappourt Taproom.

Seminar: Thursday June 16, 4-5pm at NCRC B10 Research Auditorium

Zoom link: https://umich.zoom.us/j/95851043507
Passcode: 716807

 

Meu Pornnoppadol, MS, PhD Candidate: “Development of a bispecific brain shuttle for increased delivery of neuroprotective antibodies”

Meu is a PhD candidate in the Tessier Lab in the Department of Pharmaceutical Sciences. He received his B.E. at Chulalongkorn University, Thailand and his Masters Degree at the Korea Advanced Institute of Science and Technology (KAIST), South Korea.

Research Focus: Biologics are one of the fastest growing classes of therapeutics. However, delivery of these drugs for treatment of brain diseases is mainly hindered by the blood-brain barrier (BBB). Meu’s research focuses on engineering bispecific antibodies to cross  the BBB and improve drug delivery to the brain.

 

Santiago Haase, PhD: “Harnessing the link between genomic instability and immune activation to target G34R histone-mutant pediatric glioma” 

Dr. Haase is a Research Specialist senior in the Castro-Lowenstein Lab. Dr. Haase work aims to develop rationally designed treatments for a type of pediatric high-grade glioma (pHGG) characterized by the expression of a mutation in a histone gene (histone G34R-mutant pHGG). We uncovered vulnerabilities associated with impaired DNA-damage response and genomic instability in G34R-mutant pHGG and proved that these defects alter the immunological response of the host against G34R tumors. Our findings prompted us to evaluate treatments involving the pharmacological inhibition of the DNA damage response and the immunological activation of the cGAS-STING pathway as novel therapeutic alternatives for G34R-mutant pHGG.

 

The BIBC will be hosting a social hour following the seminar at Rappourt Taproom across the street from NCRC B10 from 5:30-7pm.

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