BIBC researchers actively contribute to the the research and education mission of U-M through their scholarly works.

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

Characterization of Blood–Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains

Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy

Phospholipids impact the protective effects of HDL-mimetic nanodiscs against lipopolysaccharide-induced inflammation

Comprehensive sampling of the lung microbiome in early-stage non–small cell lung cancer

Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents

Transcranial Histotripsy Clot and Tissue Ablation for Intracerebral Hemorrhage Evacuation and Other Brain Applications

Unique characteristics of the tumor immune microenvironment in young patients with metastatic colorectal cancer

Molecular Analysis of Liquid Vitreous Biopsy Reveals Occult Lymphoma Following Cytology-Negative Biopsies of the Brain and Vitreous

Low-parameter supervised learning models can discriminate pseudoprogression and true progression in non-perfusion-based MRI

A road map for the treatment of pediatric diffuse midline glioma

Aqueous remote loading of model cationic peptides in uncapped poly (lactide-co-glycolide) microspheres for long-term controlled release

Combined cytotoxic and immune-stimulatory gene therapy using Ad-TK and Ad-Flt3L: Translational developments from rodents to glioma patients.

Combined cytotoxic and immune-stimulatory gene therapy for glioma–Authors’ reply

Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy

Antibiotic nanoparticles boost antitumor immunity

M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance

Engineering and Delivery of cGAS-STING Immunomodulators for the Immunotherapy of Cancer and Autoimmune Diseases

Nanodiscs: Game changer nano-therapeutics and structural biology tools

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024 Featured Updates to the NCCN Guidelines

Association of graph-based spatial features with overall survival status of glioblastoma patients

Fluorine 18–labeled Somatostatin Analog Improves Detection of Neuroendocrine Tumors

Identification of Excellent Prognosis IDH Wildtype Glioblastomas Using Genomic and Metabolic Profiling

Tumor radiogenomics in gliomas with Bayesian layered variable selection

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer

Innovative Photoacoustic Tomography-MRI Technology for Preclinical Molecular Imaging

A hybrid breast cancer/mesenchymal stem cell population enhances chemoresistance and metastasis

20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways.

Concurrent Lapatinib With Brain Radiation Therapy in Patients With HER2+ Breast Cancer With Brain Metastases: NRG Oncology-KROG/RTOG 1119 Phase 2 Randomized Trial

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Deferoxamine Therapy for Hemorrhagic Transformation Following Brain Ischemia

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

Simplifying complex antibody engineering using machine learning

LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function

Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy

Unlocking glioma genetics with deep learning

National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities

Sabotaging the protein factory to overcome glioma stem cell resistance

Therapeutic applications of viral vectors

Single-dose injectable nanovaccine-in-hydrogel for robust immunotherapy of large tumors with abscopal effect.

Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

A Scalable Engineered Extracellular Matrix Platform to Expand Tumor Cells

Enzyme‐based Synthetic Protein Nanoparticles as Colloidal Antioxidants

Recurrent and convolutional neural networks for sequential multispectral optoacoustic tomography (MSOT) imaging

Enzyme-Based Synthetic Protein Nanoparticles as Colloidal Antioxidants

Miniaturized microarray-format digital ELISA enabled by lithographic protein patterning

First-in-Class NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) Antagonist for the Treatment of Pancreatic Cancer

Central Nervous System, Peripheral Nervous System, and Eye

Spontaneously hypertensive rats can become hydrocephalic despite undisturbed secretion and drainage of cerebrospinal fluid

Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04)

β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer

OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology

IndepthPathway: an integrated tool for in-depth pathway enrichment analysis based on single-cell sequencing data

Histotripsy Treatment of Murine Brain and Glioma: Temporal Profile of Magnetic Resonance Imaging and Histological Characteristics Post-treatment

Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells

CD30 expression in cutaneous B-cell lymphomas

Genomics driven precision oncology in advanced biliary tract cancer improves survival

Mechanisms of cerebrospinal fluid and brain interstitial fluid production

Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Recent Progress in Preparing Nonwoven Nanofibers via Needleless Electrospinning

Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage

Gelatin methacryloyl hydrogel as an injectable scaffold with multi-therapeutic effects to promote antimicrobial disinfection and angiogenesis for regenerative endodontics

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging

Influence of encapsulation variables on formation of leuprolide-loaded PLGA microspheres

IMPACT the Brain: A Team-Based Approach to Management of Metastatic Breast Cancer with CNS Metastases

Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis

Abstract 1322: Comparison of brain extracellular matrices in a blood brain barrier organ on a chip model

In vitro degradation and erosion behavior of commercial PLGAs used for controlled drug delivery

Abstract 6037: Identification of collateral lethal targets in cancers using integrated machine learning and flux analysis platform for personalized metabolic therapy

Abstract 3921: Malic enzyme 2 identified as metabolic target in triple-negative breast cancers with increased serine biosynthesis

Abstract 5592: Expansion and characterization on ALK positive NSCLC circulating tumor cells isolated using a size based inertial microfluidic Labyrinth device

Blood–Brain Barrier Remodeling in an Organ‐on‐a‐Chip Device Showing Dkk1 to be a Regulator of Early Metastasis

Chemical and Topological Control of Surfaces Using Functional Parylene Coatings

Instrumentation for histotripsy ultrasound therapy: Evolution toward the clinic

Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through a ROS-dependent mechanism

Targeting SWI/SNF ATPases in H3. 3K27M diffuse intrinsic pontine gliomas

Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Abstract LB163: A microfluidic platform for developing circulating tumor cells (CTCs) organoids for precision medicine in pancreatic cancer

Characterization of exparel bupivacaine multivesicular liposomes

Systematic Studies into the Area Selectivity of Chemical Vapor Deposition Polymerization

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

A year in review: brain barriers and brain fluids research in 2022

Speed reading the epigenome and genome

Emerging immunotherapeutics for immune activation and tolerance

Genetic disorders and genetic manipulation at the blood-brain barriers

Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display

Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging

Unlocking the promise of systemic STING agonist for cancer immunotherapy

Efficacy and toxicity with radiation field designs and concurrent temozolomide for CNS lymphoma

Triple-negative breast cancer cells invade adipocyte/preadipocyte-encapsulating geometrically inverted mammary organoids

A Randomized Phase II Trial of Concurrent Bevacizumab and Reirradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma.

Highly Recurrent IDH1 Mutations in Prostate Cancer With Psammomatous Calcification

Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness

Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1

Epidemiology of Chiari I Malformation and Syringomyelia

Unlocking the potential of agonist antibodies for treating cancer using antibody engineering

Brain edema formation and therapy after intracerebral hemorrhage

Gene Therapy for High Grade Glioma: The Clinical Experience

Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

NCCN GUIDELINES® INSIGHTS: Central Nervous System Cancers, Version 2.2022

Perinatal Lead Exposure Promotes Sex-Specific Epigenetic Programming of Disease-Relevant Pathways in Mouse Heart

Porous PDMS-Based Microsystem (ExoSponge) for Rapid Cost-Effective Tumor Extracellular Vesicle Isolation and Mass Spectrometry-Based Metabolic Biomarker Screening

Establishing the suitability of model-integrated evidence to demonstrate bioequivalence for long-acting injectable and implantable drug products: Summary of workshop

Antibody-Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

Inhibition of Protein Disulfide Isomerase (PDIA1) Leads to Proteasome-Mediated Degradation of Ubiquitin-like PHD and RING Finger Domain-Containing Protein 1 (UHRF1) and Increased Sensitivity of Glioblastoma Cells to Topoisomerase II Inhibitors

Impact of epigenetic reprogramming on antitumor immune responses in glioma

Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination with Extension of Survival among Patients with Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial

Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation

Metastatic prostate cancer diagnosed by fine-needle aspiration: Contemporary cytopathologic and biomarker assessment with clinical correlates

Systematic evaluation of the effect of different apolipoprotein A-I mimetic peptides on the performance of synthetic high-density lipoproteins in vitro and in vivo

Methods and Impact for Using Federated Learning to Collaborate on Clinical Research

Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors

High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level

Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer

Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

Regulation of DNA damage response by trimeric G-proteins

Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer

Repeatability of Quantitative Magnetic Resonance Imaging Biomarkers in the Tibia Bone Marrow of a Murine Myelofibrosis Model

Glymphatic system and post-hemorrhagic hydrocephalus

Validation of the Combination Gleason Score as an Independent Favorable Prognostic Factor in Prostate Cancer Treated With Dose-Escalated Radiation Therapy

Mucopenetrating Janus Nanoparticles For Field-Coverage Oral Cancer Chemoprevention

Hepatic and Renal Histotripsy in an Anticoagulated Porcine Model

Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

Emergence of Structural Phosphorescence in Free-Standing, Laterally Organized Polymer Nanofiber Membranes

A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring

Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology

Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials

Cancer-associated fibroblasts: challenges and opportunities

Physicochemical characterization and functionality comparison of Humira®(adalimumab), Remicade®(infliximab) and Simponi Aria® (golimumab)

Iron-Induced Hydrocephalus: the Role of Choroid Plexus Stromal Macrophages

102 AI-Based Molecular Classification of Diffuse Gliomas using Rapid, Label-Free Optical Imaging

Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse

Magnetic Resonance Thermometry Targeting for Magnetic Resonance–Guided Histotripsy Treatments

STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications

A comparison of ventricular volume and linear indices in predicting shunt dependence in aneurysmal subarachnoid hemorrhage

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery

LSD1 promotes prostate cancer cell reprogramming by repressing TP53 signaling independently of its demethylase function

Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance”.

G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy

Directed evolution of conformation-specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations

Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies

Modularly Programmable Nanoparticle Vaccine Based on Polyethyleneimine for Personalized Cancer Immunotherapy

On‐Chip Biogenesis of Circulating NK Cell‐Derived Exosomes in Non‐Small Cell Lung Cancer Exhibits Antitumoral Activity

A Phase II Study of Dose-Intensified Chemoradiation Using Biologically-Based Target Volume Definition in Patients with Newly Diagnosed Glioblastoma

Proteogenomic and metabolomic characterization of human glioblastoma

Targeting gliomas with STAT3-silencing nanoparticles

Label-free brain tumor imaging using Raman-based methods

DDRE-30 Therapeutic Targeting of Disrupted Metabolic State in Diffuse Intrinsic Pointe Glioma

Inhibition of 2-Hydroxyglutarate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity in Mice

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

Current Approaches for Glioma Gene Therapy and Virotherapy

Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas