Commentary: The discrete charm of oncolytic viruses: Toward the finish line

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The discrete charm of oncolytic viruses: Toward the finish line
By Pedro R. Lowenstein, Maria Luisa Varela, and Maria G. Castro
Published in Cancer Cell (Cell Press)

This insightful commentary in Cancer Cell explores the growing promise of oncolytic viruses (OVs) in treating aggressive cancers, including brain tumors. The authors highlight recent advances in replicating adenoviruses and HSV-1 with therapeutic genes, innovative delivery strategies, and encouraging clinical trial results. The piece also delves into mechanisms of action and outlines strategies to enhance OV efficacy in the clinic.

Read the full article here: https://www.sciencedirect.com/science/article/abs/pii/S1535610825001114