New Publication Alert: Local controlled release of stabilized monoclonal antibodies

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Research manuscript accepted in Journal of Controlled Release

Local controlled release of stabilized monoclonal antibodies

By Rae Sung Chang#, Jennifer Walker#, Anzar A Mujeeb, Padma Kadiyala, Karthik Pisupati, Jeffrey Jamison, Anna Schwendeman, Yusuf Haggag, David A. Antonetti, Maria G. Castro, and Steven P. Schwendeman*

A novel biodegradable PLGA-based delivery system has been developed to enable long-term, localized release of monoclonal antibodies (mAbs) and their fragments. This platform addresses challenges in treating diseases like wet age-related macular degeneration (AMD) and glioblastoma (GBM) by providing sustained, controlled exposure with a single injection. Promising results in preclinical models suggest its potential as a transformative approach for mAb therapy in hard-to-reach tissues.

Access the full article here after publication: https://doi.org/10.1016/j.jconrel.2025.113743