News
Keynote Spotlight: Dr. Pedro Lowenstein’s Breakthrough Talks on Brain Tumor Biology
July 24, 2025Dr. Pedro Lowenstein delivered keynote talks at two major 2025 conferences, presenting groundbreaking research on the liquid crystal-like organization of malignant brain tumors and its implications for therapy.
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Research Spotlight: Cracking the Code of Recurrence in Pediatric Brain Cancer
July 24, 2025A new grant from the Pediatric Cancer Foundation will support research by Drs. Castro, Lowenstein, and Muraszko to understand and overcome recurrence in G34-mutant pediatric brain tumors.
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Standing Room Only for Steve’s Talk at NTUSP!
July 24, 2025Dr. Steven Schwendeman gave a packed talk at National Taiwan University on PLGA microencapsulation and peptide delivery.
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Featured in Michigan Today: Science is a Team Sport
May 13, 2025Drs. Maria Castro and Pedro Lowenstein are featured in Michigan Today for their pioneering work in brain cancer research. The article highlights their decades-long collaboration, which led to a first-in-human clinical trial and showcases the power of team science in driving innovation.
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Featured in Health Lab: Researchers Use Nanoparticles to Target Glioblastoma in Mice
April 28, 2025The collaborative research between Dr. Maria G. Castro’s and Dr. Anna Schwendeman’s labs at the University of Michigan, featured in Health Lab, showcases their groundbreaking nanoparticle-based therapy for glioblastoma. The study also highlights how combining their approach with radiation therapy significantly enhances survival outcomes in mouse models.
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???? New Research Alert: Collaborative Breakthrough in Glioma Therapy
April 23, 2025A recent collaborative study from the Castro and Schwendeman labs showcases the therapeutic potential of HDL nanodiscs delivering LXR agonists, demonstrating reduced tumor burden and long-term survival benefits in a mouse glioma model. Published in Small (2025).
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Upcoming Publication (In Press): Peripheral blood mononuclear cell (PBMC)- based functional evaluation of human T cell response to suppressive cells and immune-oncology therapeutics
April 16, 2025This new chapter presents in vitro assays to evaluate T cell function under immunosuppressive conditions, offering insights into how immunotherapies can restore anti-tumor T cell responses.
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New Publication Alert: Local controlled release of stabilized monoclonal antibodies
April 16, 2025A new biodegradable delivery system enables long-term, localized release of monoclonal antibodies, showing promising results in preclinical models of wet AMD and glioblastoma. This platform could expand antibody-based therapies to hard-to-reach tissues.
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Commentary: The discrete charm of oncolytic viruses: Toward the finish line
April 16, 2025An expert commentary in Cancer Cell highlights emerging advancements in oncolytic virus therapies, including engineered viral platforms and delivery strategies showing promise against aggressive cancers such as brain tumors.
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